Search results for " maximal dentate activation"

showing 4 items of 4 documents

Hippocampal hyperexcitability is modulated by microtubule-active agent: evidence from in vivo and in vitro epilepsy models in the rat

2016

The involvement of microtubule dynamics on bioelectric activity of neurons and neurotransmission represents a fascinating target of research in the context of neural excitability. It has been reported that alteration of microtubule cytoskeleton can lead to profound modifications of neural functioning, with a putative impact on hyperexcitability phenomena. Altogether, in the present study we pointed at exploring the outcomes of modulating the degree of microtubule polymerization in two electrophysiological epileptiform activity in the rat hippocampus. To this aim, we used in vivo Maximal Dentate Activation (MDA) and in vitro hippocampal epileptiform bursting activity (HEBA) paradigms to asse…

0301 basic medicinehippocampusPaclitaxel.HippocampusContext (language use)BiologyNeurotransmissionHippocampal formationSettore BIO/09 - Fisiologialcsh:RC321-571Microtubule polymerization03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compoundpaclitaxel0302 clinical medicineMicrotubulemedicinelcsh:Neurosciences. Biological psychiatry. NeuropsychiatryOriginal ResearchNeurotoxicitymedicine.diseaseelectrophysiologyNocodazole030104 developmental biologynocodazolechemistryepilepsyhippocampus epilepsy maximal dentate activation microtubule electrophysiology nocodazole paclitaxel.maximal dentate activationNeuroscience030217 neurology & neurosurgeryNeurosciencemicrotubule
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Neuronal nitric oxide synthase is involved in CB/TRPV1 signalling: Focus on control of hippocampal hyperexcitability

2017

Cannabinoids (CB), transient receptors potential vanilloid type 1 (TRPV1) and nitric oxide (NO) were found to be interlinked in regulating some neuronal functions such as membrane excitability and synaptic transmission. TRPV1 play a fundamental role since it represents a synaptic target for CB that triggers several downstream cellular pathways. In this regard, recent evidence report that TRPV1 could influence NO production by modulating neuronal NO synthase (nNOS) activity. In the present research, we pointed to manipulate nNOS function to assess its role on TRPV1 signalling in hyperexcitability conditions elicited in the dentate gyrus of hippocampal formation. The activation of TRPV1 recep…

Male0301 basic medicineTime FactorsAction PotentialsHippocampusStimulationNitric Oxide Synthase Type IHippocampal formationHippocampusSettore BIO/09 - Fisiologia0302 clinical medicineRosaniline DyesEnzyme InhibitorsChemistryElectrophysiologyNeurologyExcitatory postsynaptic potentialAnticonvulsantsSignal TransductionAgonistIndazolesmedicine.drug_classMorpholinesTRPV1TRPV Cation ChannelsMaximal Dentate ActivationNaphthalenesNeurotransmissionArginineTransient receptors potential vanilloid type 103 medical and health sciencesHippocampumedicineAnimalsRats WistarCannabinoidAnalysis of VarianceCannabinoidsDentate gyrusNitric oxideElectric StimulationBenzoxazinesRats030104 developmental biologynervous systemSensory System AgentsCannabinoids; Electrophysiology; Hippocampus; Maximal Dentate Activation; Nitric oxide; Transient receptors potential vanilloid type 1; Neurology; Neurology (clinical)Neurology (clinical)CapsaicinNeuroscience030217 neurology & neurosurgeryEpilepsy Research
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Involvement of nitric oxide-soluble guanylyl cyclase pathway in the control of maximal dentate gyrus activation in the rat.

2006

Summary Nitric oxide=soluble Guanylyl cyclase (NO=sGC) pathway on the maximal dentate gyrus activation (MDA) was studied in rats. The cerebral NO levels were modified by administrating 7-Nitroindazole (7-NI), a selective inhibitor of neuronal NOS, and L-arginine, a precursor of the synthesis of NO. 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ), a specific inhibitor of the NO-sGC pathway, was administered to study the involvement of cGMP pathway. The epileptic activity of the dentate gyrus was obtained through the repetitive stimulation of the angular bundle; MDA parameters studied were: onset time, MDA duration and post-stimulus afterdischarge (AD) duration. 7-NI caused an increase of M…

Malemedicine.medical_specialtyIndazolesArginineNitric Oxide Synthase Type IIIReceptors Cytoplasmic and NuclearKeywords: Maximal dentate activation nitric oxide cGMP modulationArginineNitric OxideNitric oxidechemistry.chemical_compoundSoluble Guanylyl CyclaseInternal medicineMalondialdehydeQuinoxalinesmedicineAnimalsEnzyme InhibitorsRats WistarReceptorBiological PsychiatryOxadiazolesDentate gyrusNitric Oxide Synthase Type IIIIontophoresisRatsElectrophysiologyPsychiatry and Mental healthMetabolic pathwayEndocrinologyNeurologychemistryGuanylate CyclaseDentate GyrusNeurology (clinical)Signal transductionSoluble guanylyl cyclaseSignal TransductionJournal of neural transmission (Vienna, Austria : 1996)
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Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat

2010

Different studies have been shown a clear anticonvulsant activity exerted by cannabinoids (CB) through the CB1 receptor activation. The purpose of this study was to evaluate, in an in vivo experimental model of temporal lobe epilepsy (maximal dentate gyrus activation - MDA) in the rat, the protective effect of (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone (WIN 55,212-2, CB agonist) alone or in combination with N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251, selective CB1 antagonist). Pre-treatment with AM251 (1 mg kg-1, 30 min interval) dramatically reduced the signif…

Rat Maximal dentate activation Epilepsy Control CannabinoidsSettore BIO/09 - Fisiologia
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